Philosophy of Neuroscience

Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports and objective measures is often referred to as “sleep state misperception.” Previous studies evince that this mismatch is found in both patients with insomnia and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and functional magnetic resonance imaging (fMRI) fluctuations. (...) Thirty-six healthy young adults participated in the study. Simultaneous EEG and fMRI recordings were conducted while the participants were trying to fall asleep in an MRI scanner at approximately 9:00 pm. They were awakened after achieving stable N1 or N2 sleep, or after 90 min without falling into stable sleep. Next they were asked to recall their conscious experiences from the moment immediately prior to awakening. Sixty-one instances of scheduled awakenings were collected: 21 of these after having achieved stable stage N2 sleep; 12, during stage N1 sleep; and, 20 during the waking state. Relative to those awakenings without subjective–objective discrepancy (n = 27), these awakenings with discrepancy (n = 14) were associated with lower θ power, as well as higher α, β, and γ power. Moreover, we found that participants who exhibited the discrepancy, compared with those who did not, evinced a higher amplitude of low-frequency fluctuation levels in the prefrontal cortex. These results lend support to the conjecture that the subjective–objective discrepancy is associated with central nervous system hyperarousal. (shrink)

The main message of Neuroethics is that neuroscience forces us to reconceptualize human agency as marvelously diverse and flexible. Free will can arise from unconscious brain processes. Individuals with mental disorders, including addiction and psychopathy, exhibit more agency than is often recognized. Brain interventions should be embraced with cautious optimism. Our moral intuitions, which arise from entangled reason and emotion, can generally be trusted. Nevertheless, we can and should safely enhance our brain chemistry, partly because motivated reasoning crops up in (...) everyday life and in the practice of neuroscience itself. Despite serious limitations, brain science can be useful in the courtroom and marketplace. Recognizing all this nuance leaves little room for anxious alarmism or overhype and urges an emphasis on neurodiversity. The result is a highly opinionated tour of neuroethics as an exciting field full of implications for philosophy, science, medicine, law, and public policy. (shrink)

Despite its obvious advantages, the disruptive development of neurotechnology can pose risks to fundamental freedoms. In the context of such concerns, proposals have emerged in recent years either to design human rights de novo or to update the existing ones. These new rights in the age of neurotechnology are now widely referred to as “neurorights.” In parallel, there is a considerable amount of ongoing academic work related to updating the right to freedom of thought in order to include the protection (...) of “freedom of thinking” (i.e., freedom of thought itself) and not only its social manifestations. Neurorights such as cognitive liberty, free will, mental freedom, and mental self-determination come into play here. Importantly, freedom of thought has often been considered a prerequisite for all the other fundamental freedoms and rights. In any case, just as other rights require additional legal instruments to guarantee their compliance, substantial neurorights will probably require specific complementary developments in procedural law. In relation to this, there is a long tradition of habeas corpus as an emergency remedy to enforce the rights of a citizen against illegal or arbitrary detention. More recently, the habeas data writ has been proposed and admitted in certain countries to guarantee a person’s ownership of their personal data. In this article, we propose to expand this procedural apparatus by incorporating a third habeas, which we call habeas cogitationem: a writ aimed primarily at enforcing the right to freedom of thinking (and, subsidiarily, the rest of neurorights) against direct, harmful interferences in a person’s thought process by both public and private perpetrators. (shrink)

In recent work, Mark Johnson has argued that a scientifically updated version of John Dewey’s pragmatism affords human beings the opportunity to feel at home in the world. This feeling at home, however, is not fully problematized, nor explored, nor resolved by Johnson. Rather, Johnson and his collaborators, Don Tucker (2021) and Jay Schulkin (2023), defend this updated pragmatism within the historical development of the sciences of life and mind from the twentieth century to the present day. A central theme (...) in this defense is the affinity pragmatism has with neurophenomenology, especially the enactivism seen in 4E cognition. Another theme is the future orientation of pragmatism, especially as it is focused on developments in cybernetics and artificial intelligence. Given Johnson’s previous work on expanding the number of E’s to 7, and other pragmatist suggestions for more, I argue that neuropragmatism’s development of Dewey’s conception of experience as organism-environment transaction (symbolized by the diphthong, Œ) is critical for understanding what Johnson and Tucker call the cybernetic revolution as an enchanting and welcoming future instead of a disenchanting and alienating one. (shrink)

As Jan Christoph Bublitz (2024) rightly notes, the first international declaration on neurotechnologies and human rights would set the tone for further international and domestic regulations. For t...

In their interesting paper, Susser and Cabrera (2024) apply the contextual integrity framework to brain data and mental privacy. This framework, developed by Nissenbaum (2009) and rooted in digital...

As neurotechnologies continue to develop and diffuse, this fast-paced field must be guided by robust governance frameworks in order to promote responsible innovation. The article by Bublitz (2024)...

Susser and Cabrera (2024) assess the role of bespoke neuro-privacy regulations including the creation of a novel right to mental privacy. They argue that focusing on what distinguishes mental priva...

Neurotechnologies are revolutionizing our ability to monitor and modify the brain. As these technologies gather more data, many seek to understand whether brain data raises novel privacy concerns a...

The last several years have seen vibrant debates among policymakers and scholars on whether to craft new human rights (or novel interpretations of existing ones) around neurotechnologies. These con...

The intersection of AI and neurotechnology has resulted in an increasing number of medical and non-medical applications and has sparked debate over the need for new human rights, or “neurorights,”...

This issue’s target articles cover some of the most hotly debated topics in neuroethics: neurorights and the potential establishment of international governance frameworks for neurotechnology. The...

International institutions such as UNESCO are deliberating on a new standard setting instrument for neurotechnologies. This will likely lead to the adoption of a soft law document which will be the first global document specifically tailored to neurotechnologies, setting the tone for further international or domestic regulations. While some stakeholders have been consulted, these developments have so far evaded the broader attention of the neuroscience, neurotech, and neuroethics communities. To initiate a broader debate, this target article puts to discussion twenty-five (...) considerations and desiderata for recognition by a future instrument. They are formulated at different levels of abstraction, from the big picture to technical details, seek to widen the perspective of preparatory reports and transcend the narrow debate about “neurorights” which overshadows many richer and more relevant aspects. These desiderata are not an exhaustive enumeration but a starting point for discussions about what deserves and what requires protection by an international instrument. (shrink)

The recent emergence of reprogramming technologies to convert brain cell types or epigenetically alter neurons and neural progenitors in vivo and in situ hold significant promises in brain repair and neuronal aging reversal. However, given the significant epigenetic and transcriptomic changes to components of the existing neuronal cells and network, we question if these reprogramming technology might inadvertently alter or erase memory engrams, conceivably resulting in changes in narrative identity or personality. We suggest that the nature of these alterations might (...) be less predictable compared to memory and personality changes known to be associated with diseases, drugs or brain stimulation therapies. While research in applying reprogramming technologies to neurological ailments and aging should continue, more targeted analyses should be put in place in animal experiments to gauge the severity and degree of memory alterations, and appropriate risk and benefit analyses should be conducted before these technologies move into human trials. (shrink)

Gatekeeping, or determining membership of your group, is crucial to science: the moniker ‘scientific’ is a stamp of epistemic quality or even authority. But gatekeeping in science is fraught with dangers. Gatekeepers must exclude bad science, science fraud and pseudoscience, while including the disagreeing viewpoints on which science thrives. This is a difficult tightrope, not least because gatekeeping is a human matter and can be influenced by biases such as groupthink. After spelling out these general tensions around gatekeeping in science, (...) we shed light on them with a case study from psychology. This concerns whether academic psychologists rightly or wrongly classify the applied-psychology framework of NLP (‘neuro-linguistic programming’) as unscientific and even pseudoscientific. This example of gatekeeping is particularly instructive because both the NLP community and the psychology community, we argue, make legitimate but also illegitimate moves. This case gives rise to several general insights about gatekeeping in science more generally. (shrink)

This book tackles the question of why the brain is so difficult to fully understand. In neuroscience, data are acquired and analyzed with astonishing techniques and accumulate rapidly. Nevertheless, try to explain how a person can think or why there is such a condition as schizophrenia, and it appears that we really know little. To approach these difficulties, the authors first present a number of case studies in which the operation of a neural circuit is worked out in some detail (...) and, at the same time, the functional significance of the operation is also understood. These examples are complicated in their biologic specifics but are conceptually straightforward. The examples are hoped to provoke an appreciation for what neuroscience can accomplish. The authors then develop some thoughts on how these issues can be addressed----instead of considering cognition in general, taking instead a subset of cognition that does lend itself to formal description. (shrink)

The field of modern day bioethics is relatively young and continues to constantly evolve in parallel with the ever increasingly complex nature of contemporary medical practice. These advances present clinicians with an array of therapeutic options that would have not seemed possible only a generation ago. Given these medical advances and the expansion of the academic and medicolegal field of bioethics, one would have thought that clinical decision making would have become easier. However paradoxically this has not proved to be (...) the case. Each advance may provide an answer to a particular clinical question which is almost immediately replaced by a whole new set of ethical problems that require consideration. (shrink)

A leading critic of the disruptive force of technology in education, Bernard Stiegler saw the counter-effects of artificial intelligence in undermining human agency, autonomy and individuality, rendering the role of education ever more critical. Stiegler believes that our goal is not to abandon technology but to focus our attention on its power and direction in a hypercapitalist economy. While he did not foresee the emergence of generative artificial intelligence (GAI), its rapid acceleration raises important issues for his notion of digital (...) writing as a pharmakon. In this essay, we examine Stiegler’s view on intelligence, digital writing, technological memory, and neuropower, focusing specifically on his Shanghai lecture and Nanjing Lectures. We compare Stiegler with Catherine Malabou, who examines the nature of intelligence primarily through the lens of neuroscience. We argue that Malabou’s view of neuroplasticity in human and artificial brains, and her critique of techno-narcissism in the control over technology, add an important dimension to Stiegler’s political critique of education. Finally, we examine how best to construe AI as part of a hyper-materialist epistemology that Stiegler espouses in the conclusion of his Nanjing Lectures, to bring about neganthropic knowledge through a therapeutics of care. (shrink)

Aesthetic experiences play an important role in human culture and spiritual life and are closely related to aesthetic perception and appreciation of art, music, literature and natural landscapes. With the development of neuroscience and cognitive psychology, our understanding of aesthetic experiences continues to deepen; in this context, the study of neuroplasticity has attracted widespread attention. This study explores in detail how this process affects the perception of aesthetic cognition, thereby enhancing the aesthetic experience in several key ways. The study finds (...) that neuroplasticity plays a role in the evolution of an individual’s perception and appreciation of beauty, as it facilitates adjustments in perception, attention, emotion, and cross-perceptual integration based on individual experiences. These findings provide a theoretical basis for deepening the perception and appreciation of beauty and insights to better understand and advance the aesthetic experience provided by art, music and literature. Future research will explore how to maximise the use of neuroplasticity to enhance the quality and depth of the aesthetic experience, advance the field of aesthetic psychology and art research and further enrich and satisfy individuals’ perception and experience of beauty. (shrink)

We have politics on our mind-or, rather, we have politics in different parts of our brains. In this path-breaking study, Matt Qvortrup takes the reader on a whistle stop tour through the fascinating, and sometimes frightening, world of neuropolitics; the discipline that combines neuroscience and politics, and is even being used to win elections. Putting the 'science' back into political science, The Political Brain shows how fMRI-scans can identify differences between Liberals and Conservatives, can predict our behaviour with sometimes greater (...) accuracy than surveys, and can explain the biology of uprisings, revolutions, and wars. Not merely a study of empirical evidence, the book shows how the philosophical theories of, among others, Plato, Aristotle, and Spinoza can be supported by brain scans. Along the way, it also provides an overview of the state-of-the-art knowledge of the organ that shapes our politics. The book shows that if we rely on evolutionary primitive parts of the midbrain-those engaged when we succumb to polarised politics-we stand in danger of squandering the gains we made through the last eight million years. (shrink)

The Unconscious in Neuroscience and Psychoanalysis presents a unique and provocative approach to the assimilation of these two disciplines while offering a thorough assessment of the Unconscious from a neuropsychoanalytic and Lacanian perspective. Marco Máximo Balzarini offers a comprehensive overview of Freud's theory of the unconscious and its importance within psychoanalysis, before looking to how it has been integrated into contemporary neuropsychoanalytic work. Paying close attention to the field-defining work of neuropsychoanalysts such as Mark Solms, Francois Ansermet and Pierre Magistretti, (...) Balzarini considers the dichotomy between neuroscience and psychoanalysis, and the omnipresent debate on if and how they should be integrated when working with the unconscious. Throughout, he provides a fascinating Lacanian interpretation, showing how the work of Lacan can offer a new way of developing the dialogue and understanding around this vital topic. Part of the Routledge Neuropsychoanalysis Series, this book will be of interest to any psychoanalyst seeking to explore the foundations of the relationship between neuropsychoanalytic and Lacanian ideas in their clinical and theoretical work. (shrink)

In most cases, when the left hemisphere suffers damage, there is a loss of language use. In the past, this evidence has led doctors to speculate on the presence of several language centres located in the left hemisphere, each specializing in a specific task. According to the classic model, Wernicke’s area is responsible for encoding incoming messages, while Broca’s area is responsible for encoding outgoing messages. These two areas communicate with each other thanks to specific nerve pathways (Arcuate Fasciculus). Selective (...) damage to one of these areas causes different types of speech disorders, called “aphasias”. Although this model has lost validity over time, it has strongly influenced the current classification of aphasias.Previously, scholars believed that the syntactic and semantic errors found in different types of aphasia were due to the role the left hemisphere plays in processing the formal aspects of language. In particular, they believed that the pragmatic skills of aphasics were intact or, if pragmatic deficits were present, they derived from syntactic and semantic ones. This view seems to go in the direction of the Gricean theory of implicatures. Grice argues that pragmatic processes depend on the ability to make inferences, operating on a linguistic input that already has a semantic structure. These processes enrich what is said, the proposition in a minimal sense. In other words, there is a separation between the domain of semantics and pragmatics. Each of the two fields maintains a specific character of autonomy and independence. This separation would also be maintained in the brain.However, some recent studies on neuroscience are bringing up a different picture: It would seem that the integration of extra-linguistic data in language networks would actively affect the understanding and production of verbal messages. These new results move in the direction of contextualist positions. Proponents of this trend suggest that processes of pragmatic nature intrude into semantics to determine “what is said”. Some of these processes are not required by linguistic materials; nevertheless, they affect the propositional content conveyed by the utterance. Both the recent reflections in neuroscience and those in the philosophy of language have significant consequences on the way of seeing some neuropathological conditions, such as aphasia. Semantic and syntactic deficits do not determine pragmatic deficits, as was believed. On the contrary, the pragmatics of the discourse and the clues disseminated in the context can favour communication and compensate for deficiencies at the syntactic/semantic level. (shrink)

This new monograph _Philosophy of Neuroscience_ is a novel contribution to the relevant literatures. In this book review, I first summarise its contents, and then provide several critical points for the authors to consider. Even with these critical suggestions, the book is still highly recommended to those who work in philosophy of neuroscience, philosophy in neuroscience, neurophilosophy, philosophy of psychology, and cognitive sciences.

I argue that informational models of consciousness, including those proposed by the Integrated Information Theory, don’t presuppose or entail any particular view about the physical or metaphysical nature of consciousness. Such models only tell us how certain properties of consciousness can be mathematically described, thus providing a quantitative characterization of the phenomenon of consciousness that may contribute to the development of new methods of assessment and guide the explanatory project by supplying additional constraints on theoretical proposals. While informational models are (...) in principle compatible with multiple physical interpretations, a preliminary argument in favour of the continuity between informational approaches and the mechanistic project in neuroscience can be made based on historical precedents. (shrink)

In complexity theory, both the brain and consciousness are understood as trophic systems—they consume metabolic energy when they function. Complex systems are dynamic and nonlinear and comprise diverse entities that are interdependent and interconnected in such a way that information is shared and that entities adapt to one another. Some natural complex systems are complex adaptive systems (CAS), which are sensitive to change in relation to their environments and are often chaotic. Consciousness and the neural systems mediating consciousness may be (...) modeled as CAS and, more specifically, as intelligent complex adaptive systems (ICAS), where intelligence means that a nervous system can solve problems successfully by intervening between sensory input and behavioral output. Evolution of any ICAS will result in emergent properties, particularly advanced brains. Two processes are involved in integrating experience and knowledge: the effort after meaning and the effort after truth. These efforts are mediated by the predominance given to direct experience presented to the brain's sensorium and modeling processes mediated by higher cognitive functions. Understanding consciousness as an ICAS has profound repercussions in how anthropology conceives of culture. (shrink)

Notre entreprise consiste à comparer la théorie cartésienne de l’admiration avec une théorie neuroscientifique de l’évaluation cognitive afin d’établir les filiations et les ruptures conceptuelles et doctrinales qui existent sur ce point avec le cartésianisme. Nous questionnons plus largement le passage de la pure évaluation cognitive au déclenchement des réactions corporelles dans le cadre du processus émotionnel : à quelles difficultés Descartes s’est-t-il confronté dans la description neurologique du passage de la cognition à l’émotion? Et les neurosciences parviennent-elles, dans le (...) rapport qu’elles entretiennent avec les sciences cognitives, à surmonter ces difficultés? Nous comparons ainsi l’articulation entre l’évaluation cognitive et le déclenchement des émotions que développe le neurobiologiste Joseph LeDoux dans son ouvrage The Emotional Brain et les passages où Descartes articule l’admiration avec le déclenchement des autres passions dans les Passions de l’âme et le Traité de l’homme. Cette étude nous conduira finalement à montrer ce que le philosophe peut trouver dans les théories neuroscientifiques pour surmonter certaines difficultés ouvertes par le cartésianisme. (shrink)

L’histoire des sciences est souvent comprise comme une succession de théories, les nouvelles supplantant les anciennes. Or cette conception de l’histoire des sciences ne rend pas justice à la complexité des dynamiques à l’œuvre dans le développement scientifique. Pour illustrer cela, nous nous intéressons à un type de phénomènes qui ne peut pas être décrit comme relevant d’une simple succession linéaire : la désuétude de certaines théories. Nous portons notre attention sur un cas particulier : la désuétude temporaire qui a (...) frappé la théorie de la neuroplasticité. Nous défendons l’idée que l’étude de cette théorie fait apparaître certaines des insuffisances de la conception linéaire de l’histoire des sciences. (shrink)

Visual perception of space and time has been shown to rely on context dependency, an inferential process by which the average magnitude of a series of stimuli previously experienced acts as a prior during perception. This article aims to investigate the presence and evolution of this phenomenon in early aging. Two groups of participants belonging to two different age ranges (Young Adults: average age 28.8 years old; Older Adults: average age 62.8 years old) participated in the study performing a discrimination (...) and a reproduction task, both in a spatial and temporal conditions. In particular, they were asked to evaluate lengths in the spatial domain and interval durations in the temporal one. Early aging resulted to be associated to a general decline of the perceptual acuity, which is particularly evident in the temporal condition. The context dependency phenomenon was preserved also during aging, maintaining similar levels as those exhibited by the younger group in both space and time perception. However, the older group showed a greater variability in context dependency among participants, perhaps due to different strategies used to face a higher uncertainty in the perceptual process. (shrink)